Transforming growth factor-beta 1 bifunctionally regulates murine macrophage proliferation
نویسندگان
چکیده
منابع مشابه
Transforming growth factor-beta 1 bifunctionally regulates murine macrophage proliferation.
Transforming growth factor-beta (TGF-beta) is a family of polypeptide growth factors with multiple functional activities. Recent studies suggest that TGF-beta is a selective inhibitor of hematopoietic cells. In this report, we study the effect of TGF-beta 1 on the proliferation of murine peritoneal exudate macrophages (PEM) in response to purified murine recombinant granulocyte-macrophage colon...
متن کاملTransforming growth factor- 1 regulates macrophage migration via RhoA
Brief treatment with transforming growth factor (TGF)– 1 stimulated the migration of macrophages, whereas long-term exposure decreased their migration. Cell migration stimulated by TGF1 was markedly inhibited by 10 g/mL Tat-C3 exoenzyme. TGF1 increased mRNA and protein levels of macrophage inflammatory protein (MIP)–1 in the initial period, and these effects also were inhibited by 10 g/mL Tat-C...
متن کاملTransforming growth factor-beta 1 regulates axon/Schwann cell interactions
We have investigated the potential regulatory role of TGF-beta in the interactions of neurons and Schwann cells using an in vitro myelinating system. Purified populations of neurons and Schwann cells, grown alone or in coculture, secrete readily detectable levels of the three mammalian isoforms of TGF-beta; in each case, virtually all of the TGF-beta activity detected is latent. Expression of T...
متن کاملInterleukin-1 beta regulates proximal tubular cell transforming growth factor beta-1 signalling.
BACKGROUND Increased transforming growth factor beta-1 (TGF beta) expression in the kidney is central not only to the pathogenesis of tubulointerstitial fibrosis but also in repair following acute injury. Recent work suggests that pro-inflammatory cytokines may determine epithelial cell responses to TGF beta in the contexts of acute injury and chronic wounding. METHODS In this study, we exami...
متن کاملNeurons promote macrophage proliferation by producing transforming growth factor-beta2.
The infiltration of bone marrow-derived macrophages into the CNS contributes to growth and reactions of microglia during development or after brain injury. The proliferation of microglial cells is stimulated by colony-stimulating factor 1 (CSF-1), an astrocyte-produced growth factor that acts on mononuclear phagocytes. In the present study, we have shown, using an in vitro model system, that ro...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Blood
سال: 1992
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood.v79.7.1679.1679